DEAR EDITOR, Transient acantholytic dermatosis (TAD), also known as Grover disease (GD), is a papulovesicular polymorphic eruption more commonly reported in elderly white men. The main histological feature is an epidermal acantholysis associated with different degrees of dyskeratosis. The aetiology and pathogenesis remain unclear, but several local or systemic, potentially triggering conditions have been linked with this entity, including high body temperature, sweating, acute ultraviolet exposure, drug intake or internal neoplasms. Recently, a higher than expected incidence of TAD has been described with the use of BRAF inhibitors in metastatic melanoma but the coexistence of an underlying malignancy, a condition classically associated with TAD, might represent a confounding factor.

Ipilimumab, a monoclonal antibody targeting the immunological checkpoint inhibitor, cytotoxic T lymphocyte-associated antigen (CTLA)-4, can restore the antitumoral functions of cytotoxic T cells and is currently widely used in advanced melanoma. Rash and pruritus are commonly reported during this treatment but, to our knowledge, GD had never been reported in this setting.