Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries
K Maruyama, S Tomizawa, N Shimabukuro, T Fukuda… - Nephron, 1989 - karger.com
K Maruyama, S Tomizawa, N Shimabukuro, T Fukuda, T Johshita, T Kuroume
Nephron, 1989•karger.comThe effect on the kidney capillaries of T lymphocyte culture supernatants from patients with
minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats.
The supernatants of T lymphocyte cultures from nephrotic patients induced significant
proteinuria and a reduction of anionic sites in the glomerular basement membrane of the
kidneys in the rats. These changes were not produced in rats receiving equivalent
supernatants from healthy controls.
minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats.
The supernatants of T lymphocyte cultures from nephrotic patients induced significant
proteinuria and a reduction of anionic sites in the glomerular basement membrane of the
kidneys in the rats. These changes were not produced in rats receiving equivalent
supernatants from healthy controls.
Abstract
The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.
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