Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS),
characterized by intense proteinuria leading to edema and intravascular volume depletion.
In adults, it accounts for approximately 15% of patients with idiopathic NS, reaching a much
higher percentage at younger ages, up to 70%–90% in children> 1 year of age. In the
pediatric setting, a renal biopsy is usually not performed if presentation is typical and the
patient responds to therapy with oral prednisone at conventional doses. Therefore, in this …